Gluconeogenesis

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Anecdotal observations by John Thomas

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Gluconeogenesis: is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates.

From breakdown of proteins, these substrates include glucogenic amino acids (not ketogenic amino acids derived from breakdown of ketones); from breakdown of lipids (such as triglycerides), they include glycerol, odd-chain fatty acids (although not even-chain fatty acids, see below); and from other steps in metabolism they include pyruvate and lactate.

Gluconeogenesis is one of several main mechanisms used by humans and many other animals to maintain blood glucose levels, avoiding low levels (hypoglycemia). Other means include the degradation of glycogen (glycogenolysis) and fatty acid catabolism.

Gluconeogenesis is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms.In vertebrates, gluconeogenesis takes place mainly in the liver and, to a lesser extent, in the cortex of the kidneys.

Overview

The body is designed to survive on carbohydrates, fats and proteins and will, IF GIVEN NO CHOICE, survive on any one of the above, but there are metabolic consequences for forced existence on dependence on one energy group.

Pre-diabetes and insulin-resistance are example of state of modified metabolic dysfunction that sets the stage for systemic low-grade inflammation and manifestation of cancer, diabetes, arthritis and cardiovascular/heart disorders.

Suggestions

  1. Change your lifestyle and your diet.
  2. Embrace Young Again Club Protocols.
  3. Ask for help and be open to new ideas.

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