Insulin/Leptin/Adrenaline Resistance.

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Anecdotal observations by John Thomas

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Insulin/Leptin/Adrenaline Resistance: is failure of the cells (and organs) to respond to the normal actions of the hormones, insulin, leptin and Adrenaline


If the body is unable to recognize and respond to regulatory hormones insulin, leptin and adrenaline, i leads to elevated, circulating hormones and systemic inflammation. Inflammation restricts blood and lymph circulation further impairing the healing process.

“Resistance” also refers to poor fat cell response to stimulation. When fat cells become leptin resistant, they do not respond to adrenaline stimulation; they become sluggish and accumulate more fat, more easily and refuse to give up stored fat. Resistance drives obesity.

Healthy metabolism is highly dependent upon hormonal balance.

Stress, anxiety, and the ability to cope with daily life are drivers and side effects of hormonal resistance.  Adrenal burn-out and low thyroid function are two very common responses to insulin and leptin resistance.

Adrenaline resistance plays a MAJOR role in sex hormone management, especially in females which partly explains why stress and anxiety burden female hormone balance which is often blamed on depression, fatigue and poor sleep.

Moodiness and temper swings in both sexes goes hand in hand with hormone resistance. Other effects are low energy, food cravings, aching joints, edema, tinnitus and vision issues.

The body restores hormonal balance when insulin, leptin and adrenaline resistance is corrected using the ReVive Protocol.

A key element in the protocol is to assist the body in dissolving of sugar-based brain plaque blocking brain receptor function.

For a full discussion of hormone resistance, see Special Insights,

Read Special Insights, Pre-Diabetes & Aging in Archive link below.

Also see, Special Insights, Change Your Food Habits, Change Your Life by clicking hyperlink.


  1. Change your lifestyle and your diet.
  2. Embrace Young Again Club Protocols.
  3. Ask for help and be open to new ideas.

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