Insulin (resistance & dependence)

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Anecdotal observations by John Thomas

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Insulin resistance: a condition where cells fail to respond to the normal actions of the hormone insulin; hence, ‘resistance’ and inflammation throughout the body.

Insulin Dependence: where the diabetic does not make insulin and is, therefore, dependence on outside sources of insulin which is synthetic in origin.  Dependence follows long periods of resistance followed by pancreas exhaustion.


This condition is related to leptin resistance by receptors in the brain responsible for management of insulin and blood sugar levels.

Leptin acts as a counter signal for the body, shutting down insulin production and signalling satiation so eating stops.  Leptin is made by fat cells.

Leptin resistance is common for people who are always hungry and overeat.  The problem affects most people from children to adults, and especially if you are over age 35.

If you are obese or are carrying belly fat, you are likely BOTH insulin and leptin resistant.

Insufficient production of insulin by the islet cells of the pancreas results in elevated blood sugar levels between 90-130 which is a pre-diabetic condition that is followed by diabetes mellitus Type 2 where sugar numbers are 140-170 +.  Once the cells die, you become insulin dependent.

Behind neuropathy, hypothyroidism, Alzheimer’s, Parkinson’s and Huntington’s, you will discover that insulin/leptin resistance is a big factor driving inflammation that typifies these conditions.  These neurological challenges are actually Type 3, diabetes of the brain.

Insulin resistance and leptin resistance are autoimmune responses that the body can correct if provided the means; meaning, dietary changes, improvement in digestive capability, gut porosity, intestinal inflammation and bowel and liver issues AND MOST IMPORTANTLY, reversal of fungal mycotoxin takeover of body metabolism.

For women with hormonal difficulties, particularly menopausal and post menopausal issues, it is important to understand that leptin and insulin resistance influence both the adrenals and thyroid, hormonal balance, sweats, hot flashes and sleep.  And, again fungus control of the body.

Lastly, there is STRONG evidence that cognitive issues from Alzheimer’s and Parkinson’s to vascular dimentia, brain fog, ADD, ADHD, Asperger’s and autism are directly related to low-grade inflammation of the brain [Type 3 diabetes] and adrenaline resistance.

Please read Special Insights, Premature Aging & Pre-diabetes by clicking hyperlink.

Ask for guidance.


  1. Change your lifestyle and your diet.
  2. Embrace Young Again Club Protocols.
  3. Ask for help and be open to new ideas.

See Diabetes Mellitus and Autoimmune Attack Cycle in glossary.

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