Epigenome (beyond DNA)

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Anecdotal observations by John Thomas

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Epigenome: the biological complex system of microorganisms that control and orchestrate the  the human genome [DNA.]

To understand more on issues involving fungal infestation of human DNA, read Special Insights, The Missing Diagnosis and the Mold & Fungus Protocol.


The debate over nurture vs. nature until recently was premised upon the idea that our phenotypes (the total of our characteristics) are determined by DNA; that everything about the body is “fixed”  and predetermined.

We now know that DNA is very much affected by external factors and that these influences are heritable by offspring not by way of DNA but by the epigenome.  Experiences can and do have profound effect upon how the female which is the carrier of mitochondrial DNA and the most consistent and dependable marker for tracing genetic blood lines.

The differences expressed in different cell types do not come from only the genome.  In other words, DNA is an operating system and road map controlled by the epigenome.

From where does the complexity of the human genome come form?  The answer is to be found in the epigenome which is similar to a gene regulatory system that includes various mechanisms for switching specific genes on or off when a stimulus is present.

For example, regulatory hormones such as: leptin, insulin, adrenaline, cortisol and glucagon have profound effect upon DNA and genes and how the body regulates and functions.  Hormonal resistance is fundamental to every aspect of our beings; and the Autoimmune Attack Cycle and Sugar/Alcohol Cycle are involved in autoimmune responses where the body attacks itself. Please read Special Insights, Change Your Food Habits, Change Your Life, here.

The two mechanisms controlling genome expression are DNA methylation and DNA acetylation.  These are the off/on switches for the process.  Methylation means that when a methyl group (ch3) attaches to a gene it stops that gene’s expression and vise versa for acetylation.  The stimuli humans experience have profoundly huge effects upon gene expression.  Some of the factors are: stress, diet, malnourishment, smoking exercise and many more.

While each individual’s (phenotype) may find its origins at the genetic level, epigenetic influences that dictate how the genes express.  Factors outside an individual’s control both form and alter the epigenome uniquely.  These factors cause us to accrue “tags” on our DNA that awaken or depress gene expression.

DNA sequencing is not the final word on understanding human biology.  Experiences are passed on to offspring by way of the epigenome. See ‘terrain’ in Glossary link below.


  1. Change your lifestyle and your diet.
  2. Embrace Young Again Club Protocols.
  3. Ask for help and be open to new ideas.

Also see Germ Theory of Disease, ‘epigenetics’ and DNA in Glossary link below.

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